Table Of Content

FORSKNINGSPROSJEKTER - NASJONALE FUNKSJONER - NASJONALE OG REGIONALE KOMPETANSESENTRE Faglig rapportering 2006 HELSE VEST 1 Forord Faglig rapportering 2006 har det nysgjerrige barnet på forsiden. Rekruttering til forskning er en forutsetning for et levende og godt forskningsmiljø, og Det regionale samarbeidsorganet har vedtatt at inntil 60 % av de søkbare forskningsmidlene skal gå til forskerutdanning på doktorgrads- og postdoktornivå. Som en del av hovedinntrykkene fra årets rapportering setter vi litt ekstra fokus på hva som kjennetegner de rundt 70 stipendiatene som er finansiert av Helse Vests forskningsmidler. Rapporten er som tidligere år basert på elektronisk innsamlet informasjon fra landsfunksjoner, flerregionale funksjoner, nasjonale og regionale kompetansesentre, samt fra forskningsprosjekter som har fått midler fra Helse Vest RHF. • Del 1: Hovedinntrykkene fra årets rapportering • Del 2: Presentasjon av høyspesialiserte tjenester • Del 3: Presentasjon av forskningsprosjekter • Del 4: Lister og registre De innrapporterte opplysningene fra forskningsprosjektene er også tilgjengelige i et søkbart forskningsregister, som nå inneholder data fra og med 2003. Registeret er offentlig tilgjengelig på følgende nettadresse: http://www.helse-bergen.no/forskning/samarbeidsorganet/forskningsregisteret/ Regionalt kompetansesenter for klinisk forskning v/forskningsrådgiver Sølvi Lerfald og IS- konsulent Reidar Thorstensen har det redaksjonelle ansvaret for Faglig rapportering 2006. Helse Vest RHF 20. februar 2007 Odd Søreide Fagdirektør Leder for Det regionale samarbeidsorganet Det regionale samarbeidsorganets nettside: http://samarbeidsorganet.helse-vest.no/ 2 Forord........................................................................................................................................1 Del 1: Hovedinntrykk fra årsrapportering 2006 Hovedinntrykk – forskningsprosjekter og høyspesialiserte tjenester.......................................10 Årets topplister..................................................................................................................11 Høyspesialiserte tjenester........................................................................................12 Nøkkeltall..........................................................................................................................13 Kvalitetsregistre, biobanker og pågående forskningsprosjekter..............................................14 Årets topplister for nasjonale og regionale funksjoner...........................................................15 Helse Vests forskningsmidler 2006..............................................................................16 Prosjekttyper og vitenskapelig produksjon...........................................................................16 Klassifisering av prosjektene...............................................................................................17 Forskerutdanning – doktorgradsstipend...............................................................................21 Administrasjon av prosjektene............................................................................................21 Lover og forskrifter............................................................................................................22 Belønningsmidler for forskningsproduksjon....................................................................22 Del 2: Høyspesialiserte tjenester Regionale kompetansesentre Kompetansesenter for arvelig kreft..................................................................................25 Kompetansesenter for klinisk forskning............................................................................28 Kompetansesenter for lindrende behandling.....................................................................34 Kompetansesenter for sikkerhets, fengsels- og rettspsykiatri.............................................38 Kompetansesenter i sykehushygiene...............................................................................41 Regionalt akuttmedisinsk kompetansesenter (RAKOS).......................................................45 Nasjonale kompetansesentre Nasjonalt kompetansesenter i hyperbarmedisin................................................................47 Nasjonalt kompetansesenter for bevegelsesforstyrrelser....................................................50 Nasjonalt kompetansesenter for helsetjenestens kommunikasjonsberedskap (KoKom).........54 Nasjonalt kompetansesenter for leddproteser...................................................................58 Nasjonalt kompetansesenter for Multippel sklerose. Nasjonalt register................................64 Nasjonalt kompetansesenter for nefropatologi..................................................................73 Nasjonalt kompetansesenter for søvnsykdommer.............................................................76 Nasjonalt kompetansesenter i funksjonell magnetisk resonans avbildning (fMRI).................83 Nasjonalt kompetansesenter i gastroenterologisk ultrasonografi.........................................92 Nasjonalt kompetansesenter i hjemmerespiratorbehandling...............................................96 Nasjonalt kompetansesenter i porfyrisykdommer (NAPOS)..............................................100 Nasjonalt kompetansesenter i tropesykdommer og importerte infeksjonssykdommer.........103 Nasjonalt kompetansesenter i vestibulære sykdommer....................................................106 Landsfunksjoner Avansert brannskadebehandling....................................................................................109 Behandling med keratoprotese......................................................................................112 3 Strålekniv....................................................................................................................113 Landsfunksjon i elektiv hyperbarmedisinsk behandling......................................................47 Flerregionale funksjoner Behandling av barn med leppe-kjeve-ganespalte............................................................115 Cochlea implantat – behandling av voksne.....................................................................118 Episkleral brachyterapi.................................................................................................119 Intersex......................................................................................................................121 Kateterbasert ablasjonsbehandling av hjertearytmier......................................................123 Standard allogen benmargstransplantasjon....................................................................126 Del 3: Forskningsprosjekter 2006 Epidemiologisk forskning Julie Dahl...................................................................................................................128 Signe Dørheim Ho-Yen..............................................................................................130 Ove Furnes................................................................................................................132 Ellen Merete Hagen....................................................................................................134 Oddbjørn Hove...........................................................................................................135 Ane Johannessen......................................................................................................137 Svetlana Konstantinova.............................................................................................139 Jan Petter Larsen.......................................................................................................141 Birger N. Lærum........................................................................................................142 Dag Moster................................................................................................................143 Martina Moter Erichsen.............................................................................................144 Dennis W. T. Nilsen....................................................................................................145 Ottar Nygård.............................................................................................................147 Máire O'Donnell.........................................................................................................152 Eyvind Rødahl...........................................................................................................154 Sverre Sandberg........................................................................................................155 Kjell Morten Stormark................................................................................................158 Cecilie Svanes............................................................................................................159 Bjørn Egil Vikse..........................................................................................................162 Marianne Voll-Aanerud..............................................................................................164 Nina Øyen..................................................................................................................166 Dag Årsland...............................................................................................................167 Grunnforskning Marit Bakke...............................................................................................................168 Cecilie Bredrup..........................................................................................................169 Dag Fadnes...............................................................................................................172 Tord O. Fanneløp.......................................................................................................173 Harleen Grewal..........................................................................................................174 Donald Gullberg.........................................................................................................176 Alfred Halstensen......................................................................................................178 Frank Helle................................................................................................................180 Dag Arne L. Hoff.........................................................................................................181 Heike Immervoll........................................................................................................183 Bjarne M. Iversen......................................................................................................184 Hugo A. Jørgensen....................................................................................................186 Per Morten Knappskog...............................................................................................187 Sabine Leh.................................................................................................................189 4 Rolv Terje Lie.............................................................................................................190 Elisabeth Norman.......................................................................................................192 Astrid M. Olsnes.........................................................................................................193 Sharad Pathak...........................................................................................................194 Elisabeth Vaagen Samsøe...........................................................................................195 Tone Sandal..............................................................................................................196 Ruth Stavrum............................................................................................................197 Frits Allan Thorsen.....................................................................................................199 Tore Wiig...................................................................................................................171 Birgitta Åsjø...............................................................................................................201 Helsetjenesteforskning Afsaneh Bjorvatn.......................................................................................................202 Pål Davidsen.............................................................................................................203 Hans Flaatten............................................................................................................205 Kari Guldbrandsøy....................................................................................................207 Eugene Guribye.........................................................................................................208 Einar Heiervang.........................................................................................................209 Hugo Jørgensen........................................................................................................210 Elisabeth Severinsson................................................................................................211 Eldar Søreide.............................................................................................................213 Villy Våge...................................................................................................................215 Klinisk forskning Andreas Andreassen..................................................................................................217 Helga Myrseth Arnestad.............................................................................................218 Gülen Arslan.............................................................................................................219 Astvaldur Johann Arthursson......................................................................................221 Per Bakke..................................................................................................................222 Christian Beisland .....................................................................................................224 Sigbjørn Berentsen....................................................................................................225 Ansgar Berg...............................................................................................................226 Roberto Bergamaschi................................................................................................270 Arnold Berstad...........................................................................................................228 Robert Bjerknes.........................................................................................................231 Jofrid Bjørkvik...........................................................................................................233 Anne Isine Bolstad.....................................................................................................234 Eirik Bratland.............................................................................................................236 Marianne Brydøy........................................................................................................237 Trygve Brügger-Andersen.........................................................................................238 Anniken Hamang Carlsson..........................................................................................240 Kenneth Dickstein......................................................................................................241 Ludger Dorløchter.....................................................................................................242 Nezla Duric................................................................................................................243 Tomas Mikal Lind Eagan..............................................................................................244 Cathrine Ebbing.........................................................................................................245 Uwe Ehrt....................................................................................................................246 Ingeborg Bø Engelsen................................................................................................248 Lars Birger Engesæter................................................................................................250 Kari Erichsen.............................................................................................................251 Ove Furnes................................................................................................................252 Tove Giske.................................................................................................................253 Jennifer Gjerde..........................................................................................................254 5 Michaela-A. Gjerstad..................................................................................................255 Karsten Gravdal.........................................................................................................256 Amund Gulsvik...........................................................................................................258 Lasse Gøransson.......................................................................................................260 Ingfrid Salvesen Haldorsen.........................................................................................262 Torkel Harboe............................................................................................................263 Odd Havik..................................................................................................................264 Reino Heikkilä...........................................................................................................265 Christian Andre Helland..............................................................................................267 Asle Hirth...................................................................................................................269 Inge Joa.....................................................................................................................271 Jan Olav Johannessen...............................................................................................273 Synnøve Lian Johnsen................................................................................................275 Olav Klausen.............................................................................................................277 Gunn B.B. Kristensen.................................................................................................278 Jon Christian Laberg...................................................................................................280 Nina Langeland.........................................................................................................281 Alf Inge Larsen..........................................................................................................283 Terje H. Larsen..........................................................................................................284 Annette Larsen...........................................................................................................285 Katrine Tyborg Leversen.............................................................................................286 Ernst A. Lien...............................................................................................................287 Anders Lund...............................................................................................................288 Linn-Heidi Lunde........................................................................................................289 Morten Lund-Johansen..............................................................................................291 Ole Didrik Lærum.......................................................................................................292 Cord Manhenke.........................................................................................................293 Mala Naik...................................................................................................................294 Arvid Nilsen...............................................................................................................295 Tone Merete Norekvål................................................................................................296 Ottar Nygård.............................................................................................................298 Ole-Jørgen Ohm.........................................................................................................300 Jone Furlund Owe.......................................................................................................302 Volker Pönitz.............................................................................................................303 Jan Henrik Rosland....................................................................................................305 Kjetil Roth..................................................................................................................306 Esben Seljeskog........................................................................................................307 Helgi Kjartan Sigurdsson............................................................................................308 Brynjulf Stige.............................................................................................................309 Torgeir Storaas..........................................................................................................311 Eva Marianne Staal.....................................................................................................313 Ståle Sund.................................................................................................................314 Tatjana Sundic...........................................................................................................315 Lisbeth Sviland..........................................................................................................316 Håvard Søiland..........................................................................................................317 Karl Søndenaa...........................................................................................................318 Yngvild Sørebø Danielsen..........................................................................................319 Eldar Søreide.............................................................................................................321 Atle Ulvik...................................................................................................................322 Rune J. Ulvik..............................................................................................................323 Olav Karsten Vintermyr..............................................................................................325 Villy Våge...................................................................................................................326 Aina Basilier Vaage.....................................................................................................327 Øyvind Brune Vågnes.................................................................................................328 Ulrike Waje-Andreassen............................................................................................330 Stein Ørn....................................................................................................................332 Hildegunn Aarsetøy....................................................................................................334 Margrethe Aase..........................................................................................................336 6 Translasjonsforskning Lars A. Akslen............................................................................................................337 Torunn Oveland Apelseth...........................................................................................340 Thomas Arnesen........................................................................................................342 Ingeborg M. Bachmann..............................................................................................344 Jan Øystein Berle........................................................................................................346 Mona K. Beyer............................................................................................................348 Rolf Bjerkvig.............................................................................................................350 Lars Bø.......................................................................................................................352 Ranjan Chrisanthar....................................................................................................354 Anne Elisabeth Christensen........................................................................................356 Olav Dahl...................................................................................................................357 Stein Ove Døskeland..................................................................................................365 Kari Espolin Fladmark.................................................................................................367 Bjørn Tore Gjertsen...................................................................................................369 Therese Halvorsen Røst............................................................................................372 Oddbjørn Haugen.......................................................................................................374 Lars Helgeland..........................................................................................................376 Randi Hovland...........................................................................................................377 Kenneth Hugdahl.......................................................................................................379 Paul Husby................................................................................................................383 Eystein S. Husebye.....................................................................................................385 Lars Reinhard Haaheim..............................................................................................388 Jan Haavik.................................................................................................................390 Roland Jonsson..........................................................................................................393 Karl-Henning Kalland..................................................................................................395 Stian Knappskog.......................................................................................................397 James Lorens.............................................................................................................399 Steven Paul Luckman.................................................................................................400 Keijo Luukko..............................................................................................................401 Helle Lybæk...............................................................................................................402 Hiwa Malen................................................................................................................404 Aurora Martinez.........................................................................................................406 Emmet McCormack....................................................................................................408 Gunnar Mellgren........................................................................................................410 Janne Molnes.............................................................................................................411 Anders Mølster...........................................................................................................413 Pål Rasmus Njølstad..................................................................................................415 Jan Olofsson..............................................................................................................420 Anita Ryningen..........................................................................................................422 Maria Barøy Ræder.....................................................................................................424 Jarle Rørvik...............................................................................................................426 Elvira Semaeva..........................................................................................................428 Vidar M. Steen...........................................................................................................429 Anita Steinbakk.........................................................................................................431 Anette Storstein........................................................................................................432 Øyvind Sverre Svendsen.............................................................................................434 Torfinn Taxt...............................................................................................................435 Cecilie Totland...........................................................................................................436 Jan Erik Varhaug........................................................................................................437 Christian Vedeler........................................................................................................439 Mette Vesterhus........................................................................................................445 Asgaut Viste...............................................................................................................448 Harald G. Wiker………………………………………………….……...…………………………………………....449 7 Del 4: Lister og registre Tematisk oversikt over forskningsprosjektene............................................................................452 Medisinske kvalitetsregistre......................................................................................................463 Forskningsbiobanker................................................................................................................464 Avlagte doktorgrader 2006.......................................................................................................470 Belønningsmidler og prosjekter.................................................................................................471 Manglende rapportering...........................................................................................................474 Tabeller og figurer Tabell 1: Antall forskjellige vitenskapelige artikler og doktorgrader 2003-2006................................10 Tabell 2: Vitenskapelige artikler og doktorgrader 2006..................................................................10 Tabell 3: Topplister innen forfatterskap 2006 – basert på innrapporterte artikler.............................11 Tabell 4: Høyspesialiserte tjenester - fordelt på kategori og tilhørighet...........................................12 Tabell 5: Forskningsproduksjon fordelt på kategori, 2003 - 2006...................................................13 Tabell 6: Helse Vest finansierte prosjekter tilknyttet en funksjon...................................................15 Tabell 7: Forskningsprosjektene etter prosjekttype.......................................................................16 Tabell 8: Antall forskjellige vitenskapelige artikler og doktorgrader 2003-2006, prosjekter...............17 Tabell 9: Fordeling på forskningskategori, % av totalt antall (N)....................................................21 Figur 1: Vitenskapelig artikler og annen forskningsproduksjon 2003 – 2006....................................11 Figur 2: Vitenskapelige publikasjoner pr. årsverk, 2003 – 2006......................................................14 Figur 3: Forskningsprosjekter 2006 – klassifisert etter forskningskategori. Antall i hver kategori.......18 Figur 4: Prosjekter fordelt på strategiområde i Nasjonal helseplan (N=80)......................................19 8 Lerfald S, Thorstensen RC Faglig rapportering 2006, Forskningsprosjekter, Nasjonale funksjoner, Nasjonale og regionale kompetansesentre Forskningsrapport 2007-02, ISBN 978-82-8045-015-9 Trykk: Hustrykkeriet, Helse Bergen HF 1. opplag: 500 eksemplarer (2) Elektronisk versjon, Det regionale samarbeidsorganet. Regionalt kompetansesenter for klinisk forskning Sekretariatet for Det regionale samarbeidsorganet Armauer Hansens hus Haukeland Universitetssjukehus N-5021 Bergen, Norway Telefon + 47-55975535 Telefax + 47-55976088 E-mail: [email protected] ISSN 1502-6140 ISBN 978-82-8045-015-9 9 Del 1: Hovedinntrykk fra årsrapportering 2006

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"Psychometric testing of a Norwegian version of the Premature Infant Pain Profile: an acute pain . "Health care, management and guidelines of obstructive lung disease in the Nordic countries". Respir Med Read at the meeting of the Outcome Special Interest Group, AAOS, Chicago, 24. mars 2006.
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"Psychometric testing of a Norwegian version of the Premature Infant Pain Profile: an acute pain . "Health care, management and guidelines of obstructive lung disease in the Nordic countries". Respir Med Read at the meeting of the Outcome Special Interest Group, AAOS, Chicago, 24. mars 2006.

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