Integrated endocrinology

406 Pages·2012·3.62 MB·English

by  Laycock

Integrated Endocrinology

Integrated
Endocrinology
John Laycock and Karim Meeran
BothofImperialCollegeLondon
A John Wiley & Sons, Ltd., Publication
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Contents
Preface vii
1 TheMolecularBasisofHormones 1
2 TheHypothalamusandtheConceptofNeurosecretion 43
3 ThePituitaryGland(1):TheAnteriorLobe
(Adenohypophysis) 51
4 ThePituitaryGland(2):ThePosteriorLobe
(Neurohypophysis) 89
5 DiseasesofthePituitaryGland 109
6 TheGonads(1):Testes 133
7 TheGonads(2):Ovaries 155
8 TheEndocrineControlofPuberty 189
9 TheHormonesofPregnancy,ParturitionandLactation 199
10 TheAdrenalGlands(1):AdrenalCortex 211
11 TheAdrenalGlands(2):AdrenalMedulla 247
12 TheEndocrineControlofSaltandWaterBalance 259
13 TheThyroidGlandandItsIodothyronineHormones 275
14 TheIsletsofLangerhansandTheirHormones 303
15 DiabetesMellitus 325
16 TheGut–BrainAxis 337
17 Hormones,EndocrineTumoursandtheGut 343
18 TheParathyroids,theEndocrineKidneyand
CalciumRegulation 349
19 TheGeneticsofEndocrineTumours 375
20 FutureProspects 383
Index 387
v

Preface
Bothofushavealwaysbeeninspiredbytheinterestshownbyourstudents
inthesubjectofendocrinology,andwearegratefultothemforenhancing
our desire to produce a readable textbook covering the main aspects of
the subject. Because the understanding of endocrinology is enhanced by
a consideration of the clinical conditions associated with diminished or
excessiveproductionofindividualhormones,wehopethattheintegration
we have attempted between basic and clinical aspects is successful. In
addition we are grateful to our wives and families, who have given us
their continual support, and to our colleagues, in particular Waljit Dhillo
andGarethLengwhogaveusmanysuggestionsforimprovementinthose
chapterswhichtheyreadforus.
JohnLaycockandKarimMeeran
vii